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Biologique Recherche Lotion P50 1970 INCI & Conflict Matrix: pH 3.0 Multi-Acid Rules
Iconic pH 3.0 multi-acid (Lactic + PHA + BHA + Sulfur) resurfacing lotion. Extreme barrier hazard if combined with Tretinoin.
Recommended Spacing: 15 Minutes
Apply in the AM only if paired with broad-spectrum SPF 30–50+ and separated from antagonistic pH/redox actives.
In the PM, Combines Lactic Acid, Gluconolactone, Salicylic Acid, and Sulfur at pH 3.0. Strictly contraindicated in the same session with Tretinoin, Copper Peptides, or Vitamin C.
Layering low-pH keratolytic acids (pH 3.0–3.8) with nuclear retinoids strips the stratum corneum barrier, accelerates acid-catalyzed retinoid degradation, and causes severe retinoid dermatitis.
Direct acids (pH < 4.0) protonate the imidazole nitrogen of histidine in Copper Tripeptide-1, breaking the copper coordination bond and hydrolyzing peptide chains.
Applying pH 3.0 acid alongside neutral oligopeptides (ΔpH 3.2 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
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Applying pH 3.0 acid alongside neutral oligopeptides (ΔpH 3.2 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Layering low-pH keratolytic acids (pH 3.0–3.8) with nuclear retinoids strips the stratum corneum barrier, accelerates acid-catalyzed retinoid degradation, and causes severe retinoid dermatitis.
Direct acids (pH < 4.0) protonate the imidazole nitrogen of histidine in Copper Tripeptide-1, breaking the copper coordination bond and hydrolyzing peptide chains.
Applying pH 3.0 acid alongside neutral oligopeptides (ΔpH 3.2 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.0 acid alongside neutral oligopeptides (ΔpH 3.2 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Direct acids (pH < 4.0) protonate the imidazole nitrogen of histidine in Copper Tripeptide-1, breaking the copper coordination bond and hydrolyzing peptide chains.
Applying pH 3.0 acid alongside neutral oligopeptides (ΔpH 3.2 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.0 acid alongside neutral oligopeptides (ΔpH 3.2 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Immediate layering across a ΔpH 2.8 gap (> 1.8 threshold) buffers the acid's un-ionized free-acid fraction while risking transient nicotinic-acid prostaglandin D2 capillary flushing.
Immediate layering across a ΔpH 2.8 gap (> 1.8 threshold) buffers the acid's un-ionized free-acid fraction while risking transient nicotinic-acid prostaglandin D2 capillary flushing.
Immediate layering across a ΔpH 3.2 gap (> 1.8 threshold) buffers the acid's un-ionized free-acid fraction while risking transient nicotinic-acid prostaglandin D2 capillary flushing.
Applying pH 3.0 acid alongside neutral oligopeptides (ΔpH 3.2 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.0 acid alongside neutral oligopeptides (ΔpH 3.2 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Immediate layering across a ΔpH 3.2 gap (> 1.8 threshold) buffers the acid's un-ionized free-acid fraction while risking transient nicotinic-acid prostaglandin D2 capillary flushing.
Immediate layering across a ΔpH 2.8 gap (> 1.8 threshold) buffers the acid's un-ionized free-acid fraction while risking transient nicotinic-acid prostaglandin D2 capillary flushing.
Immediate layering across a ΔpH 3.2 gap (> 1.8 threshold) buffers the acid's un-ionized free-acid fraction while risking transient nicotinic-acid prostaglandin D2 capillary flushing.
Applying pH 3.0 acid alongside neutral oligopeptides (ΔpH 3.2 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.0 acid alongside neutral oligopeptides (ΔpH 3.2 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Co-layering 1% Copper Tripeptide-1 and potent retinoids in the same PM session increases stinging and risks trace Cu2+ acceleration of retinoid isomerization.
Layering low-pH keratolytic acids (pH 3.0–3.8) with nuclear retinoids strips the stratum corneum barrier, accelerates acid-catalyzed retinoid degradation, and causes severe retinoid dermatitis.
Copper ions in GHK-Cu catalyze rapid single-electron oxidation of Ascorbic Acid while low-pH Vitamin C protonates histidine and strips Cu2+ from the tripeptide.
Direct acids (pH < 4.0) protonate the imidazole nitrogen of histidine in Copper Tripeptide-1, breaking the copper coordination bond and hydrolyzing peptide chains.
Applying pH 3.0 acid alongside neutral oligopeptides (ΔpH 3.2 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.0 acid alongside neutral oligopeptides (ΔpH 3.2 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.0 acid alongside neutral oligopeptides (ΔpH 3.2 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.0 acid alongside neutral oligopeptides (ΔpH 3.2 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.0 acid alongside neutral oligopeptides (ΔpH 3.2 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.0 acid alongside neutral oligopeptides (ΔpH 3.2 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.0 acid alongside neutral oligopeptides (ΔpH 3.2 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.0 acid alongside neutral oligopeptides (ΔpH 3.2 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
- AM Prep: pH 5.5 Gentle Amino-Acid Cleanser or Water Rinse [pH 5.5 · Pat dry]
- AM Peptide Remodeling: Copper Tripeptide-1 (GHK-Cu) 1% Serum (Separated from PM Acids/Retinoids) [pH 6.2 · Apply on damp skin]
- AM Barrier + Photoprotection: Physiological Ceramide Moisturizer + Broad-Spectrum SPF 50+ PA++++ [pH 5.8 · Mandatory final step]
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Esthetician & Cosmetic Chemist FAQ
What is the formulation pH and full INCI profile of Biologique Recherche Lotion P50 1970 Balancing Exfoliator?
Biologique Recherche Lotion P50 1970 Balancing Exfoliator is formulated at pH 3 ($115). Full INCI: Water (Aqua), Gluconolactone, Lactic Acid, Glycerin, Propylene Glycol, Niacinamide, Citric Acid, Ethoxydiglycol, Magnesium Chloride, Malic Acid, Phytic Acid, Salicylic Acid, Sulfur.
Which skincare actives conflict with Biologique Recherche Lotion P50 1970 Balancing Exfoliator?
Combines Lactic Acid, Gluconolactone, Salicylic Acid, and Sulfur at pH 3.0. Strictly contraindicated in the same session with Tretinoin, Copper Peptides, or Vitamin C.
Is Biologique Recherche Lotion P50 1970 Balancing Exfoliator comedogenic or fungal-acne (Malassezia) safe?
Run the pre-loaded INCI analyzer above to inspect positional comedogenicity (0–5) and C12–C24 Malassezia lipid ester triggers for every ingredient in Lotion P50 1970 Balancing Exfoliator.