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Rx Tretinoin 0.05% Cream INCI Analysis: Hidden Isopropyl Myristate (5/5 Comedogen) & Conflicts
Prescription RAR nuclear agonist. Note: generic cream vehicle uses Isopropyl Myristate (Grade 5/5 comedogen).
Recommended Spacing: 5 Minutes
Do not apply in the AM; UV photons and oxidizing actives degrade retinoid efficacy. Wear SPF 50+ daily.
In the PM, Generic Tretinoin cream contains Isopropyl Myristate (Grade 5/5 comedogenicity + Malassezia ester). Degraded by Benzoyl Peroxide and destabilized by AHAs/BHAs.
Benzoyl Peroxide cleaves into oxygen free radicals that oxidize delicate retinoid polyene chains on contact, neutralizing >80% of Tretinoin/Retinol potency within 2 hours.
Layering low-pH keratolytic acids (pH 3.0–3.8) with nuclear retinoids strips the stratum corneum barrier, accelerates acid-catalyzed retinoid degradation, and causes severe retinoid dermatitis.
Layering low-pH keratolytic acids (pH 3.0–3.8) with nuclear retinoids strips the stratum corneum barrier, accelerates acid-catalyzed retinoid degradation, and causes severe retinoid dermatitis.
+ View 3 additional secondary ingredient interaction(s)
Layering low-pH keratolytic acids (pH 3.0–3.8) with nuclear retinoids strips the stratum corneum barrier, accelerates acid-catalyzed retinoid degradation, and causes severe retinoid dermatitis.
Stacking multiple leave-on AHA/BHA exfoliants in one routine dissolves both hydrophilic surface corneodesmosomes and lipophilic sebaceous lipids, causing acute barrier burn.
Stacking multiple leave-on AHA/BHA exfoliants in one routine dissolves both hydrophilic surface corneodesmosomes and lipophilic sebaceous lipids, causing acute barrier burn.
- AM Prep: pH 5.5 Gentle Amino-Acid Cleanser or Water Rinse [pH 5.5 · Pat dry]
- AM Antibacterial (Split from PM Retinoid): Benzoyl Peroxide 2.5%–5.5% Treatment (Prevents PM Retinoid Oxidation) [pH 5.0 · ⏱ Let dry 5 min]
- AM Barrier + Photoprotection: Physiological Ceramide Moisturizer + Broad-Spectrum SPF 50+ PA++++ [pH 5.8 · Mandatory final step]
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Esthetician & Cosmetic Chemist FAQ
What is the formulation pH and full INCI profile of Rx Dermatology Tretinoin 0.05% Cream (All-Trans Retinoic Acid)?
Rx Dermatology Tretinoin 0.05% Cream (All-Trans Retinoic Acid) is formulated at pH 5.8 ($45). Full INCI: Tretinoin 0.05%, Stearic Acid, Isopropyl Myristate, Polyoxyl 40 Stearate, Stearyl Alcohol, Xanthan Gum, Sorbic Acid, Butylated Hydroxytoluene, Purified Water.
Which skincare actives conflict with Rx Dermatology Tretinoin 0.05% Cream (All-Trans Retinoic Acid)?
Generic Tretinoin cream contains Isopropyl Myristate (Grade 5/5 comedogenicity + Malassezia ester). Degraded by Benzoyl Peroxide and destabilized by AHAs/BHAs.
Is Rx Dermatology Tretinoin 0.05% Cream (All-Trans Retinoic Acid) comedogenic or fungal-acne (Malassezia) safe?
Run the pre-loaded INCI analyzer above to inspect positional comedogenicity (0–5) and C12–C24 Malassezia lipid ester triggers for every ingredient in Tretinoin 0.05% Cream (All-Trans Retinoic Acid).