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Sunday Riley Good Genes Lactic Acid INCI Teardown: pH 2.8 Free-Acid Potency & Conflicts
Ultra-low pH 2.8 Lactic Acid treatment with high un-ionized free acid fraction. High ΔpH conflict with peptides and retinoids.
Recommended Spacing: 15 Minutes
Apply in the AM only if paired with broad-spectrum SPF 30–50+ and separated from antagonistic pH/redox actives.
In the PM, Formulated at an aggressive pH 2.8, delivering high un-ionized Lactic Acid. Never layer on the same night as Retinoids, Copper Peptides, or BHA.
Layering low-pH keratolytic acids (pH 3.0–3.8) with nuclear retinoids strips the stratum corneum barrier, accelerates acid-catalyzed retinoid degradation, and causes severe retinoid dermatitis.
Direct acids (pH < 4.0) protonate the imidazole nitrogen of histidine in Copper Tripeptide-1, breaking the copper coordination bond and hydrolyzing peptide chains.
Applying pH 2.8 acid alongside neutral oligopeptides (ΔpH 3.4 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
+ View 10 additional secondary ingredient interaction(s)
Applying pH 2.8 acid alongside neutral oligopeptides (ΔpH 3.4 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Co-layering 1% Copper Tripeptide-1 and potent retinoids in the same PM session increases stinging and risks trace Cu2+ acceleration of retinoid isomerization.
Layering low-pH keratolytic acids (pH 3.0–3.8) with nuclear retinoids strips the stratum corneum barrier, accelerates acid-catalyzed retinoid degradation, and causes severe retinoid dermatitis.
Direct acids (pH < 4.0) protonate the imidazole nitrogen of histidine in Copper Tripeptide-1, breaking the copper coordination bond and hydrolyzing peptide chains.
Applying pH 2.8 acid alongside neutral oligopeptides (ΔpH 3.4 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 2.8 acid alongside neutral oligopeptides (ΔpH 3.4 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 2.8 acid alongside neutral oligopeptides (ΔpH 3.4 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 2.8 acid alongside neutral oligopeptides (ΔpH 3.4 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 2.8 acid alongside neutral oligopeptides (ΔpH 3.4 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 2.8 acid alongside neutral oligopeptides (ΔpH 3.4 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
- AM Prep: pH 5.5 Gentle Amino-Acid Cleanser or Water Rinse [pH 5.5 · Pat dry]
- AM Peptide Remodeling: Copper Tripeptide-1 (GHK-Cu) 1% Serum (Separated from PM Acids/Retinoids) [pH 6.2 · Apply on damp skin]
- AM Barrier + Photoprotection: Physiological Ceramide Moisturizer + Broad-Spectrum SPF 50+ PA++++ [pH 5.8 · Mandatory final step]
Save Your Personalized AM/PM Glow Ritual & 9:16 Vanity Card
Includes your printable 4-Night Skin-Cycling calendar, Henderson-Hasselbalch free-acid table, and Apple-Wallet lockscreen guide.
Esthetician & Cosmetic Chemist FAQ
What is the formulation pH and full INCI profile of Sunday Riley Good Genes All-In-One Lactic Acid Treatment?
Sunday Riley Good Genes All-In-One Lactic Acid Treatment is formulated at pH 2.8 ($85). Full INCI: Water/Eau/Aqua, Dimethicone, Glycolic Acid, Caprylic/Capric Triglyceride, Squalane, Lactic Acid,PPG-12/SMDI Copolymer, Saccharomyces Cerevisiae Extract, Glycyrrhiza Glabra Root Extract.
Which skincare actives conflict with Sunday Riley Good Genes All-In-One Lactic Acid Treatment?
Formulated at an aggressive pH 2.8, delivering high un-ionized Lactic Acid. Never layer on the same night as Retinoids, Copper Peptides, or BHA.
Is Sunday Riley Good Genes All-In-One Lactic Acid Treatment comedogenic or fungal-acne (Malassezia) safe?
Run the pre-loaded INCI analyzer above to inspect positional comedogenicity (0–5) and C12–C24 Malassezia lipid ester triggers for every ingredient in Good Genes All-In-One Lactic Acid Treatment.