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The Ordinary Multi-Peptide + Copper Peptides 1% Conflicts: What Never to Mix with GHK-Cu
1% pure GHK-Cu + Matrixyl 3000 + Argireline at pH 6.2. Strictly incompatible with L-Ascorbic Acid, Glycolic Acid, and Salicylic Acid.
Recommended Spacing: 5 Minutes
Apply in the AM only if paired with broad-spectrum SPF 30–50+ and separated from antagonistic pH/redox actives.
In the PM, Strictly incompatible with L-Ascorbic Acid, Glycolic Acid, Lactic Acid, Salicylic Acid, and Kojic Acid due to histidine protonation and copper chelation.
Copper ions in GHK-Cu catalyze rapid single-electron oxidation of Ascorbic Acid while low-pH Vitamin C protonates histidine and strips Cu2+ from the tripeptide.
Direct acids (pH < 4.0) protonate the imidazole nitrogen of histidine in Copper Tripeptide-1, breaking the copper coordination bond and hydrolyzing peptide chains.
Copper ions in GHK-Cu catalyze rapid single-electron oxidation of Ascorbic Acid while low-pH Vitamin C protonates histidine and strips Cu2+ from the tripeptide.
+ View 17 additional secondary ingredient interaction(s)
Applying pH 3.2 acid alongside neutral oligopeptides (ΔpH 3.0 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.2 acid alongside neutral oligopeptides (ΔpH 3.0 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.2 acid alongside neutral oligopeptides (ΔpH 3.0 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.6 acid alongside neutral oligopeptides (ΔpH 2.6 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.2 acid alongside neutral oligopeptides (ΔpH 3.0 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.2 acid alongside neutral oligopeptides (ΔpH 3.0 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.2 acid alongside neutral oligopeptides (ΔpH 3.0 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.6 acid alongside neutral oligopeptides (ΔpH 2.6 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.2 acid alongside neutral oligopeptides (ΔpH 3.0 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.2 acid alongside neutral oligopeptides (ΔpH 3.0 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.2 acid alongside neutral oligopeptides (ΔpH 3.0 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.6 acid alongside neutral oligopeptides (ΔpH 2.6 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.2 acid alongside neutral oligopeptides (ΔpH 3.0 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.2 acid alongside neutral oligopeptides (ΔpH 3.0 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.2 acid alongside neutral oligopeptides (ΔpH 3.0 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Applying pH 3.6 acid alongside neutral oligopeptides (ΔpH 2.6 > 1.8 threshold) denatures peptide conformation and cleaves matrikine bonds.
Stacking 15%–20% L-Ascorbic Acid (pH 3.0) with AHA/BHA exfoliants (pH 3.5) overwhelms the skin’s natural buffering capacity, triggering nociceptor stinging.
- AM Prep: pH 5.5 Gentle Amino-Acid Cleanser or Water Rinse [pH 5.5 · Pat dry]
- AM Antioxidant (Low pH): L-Ascorbic Acid 15%–20% + Ferulic Acid Serum [pH 3.2 · ⏱ Wait 5 min]
- AM Barrier + Photoprotection: Physiological Ceramide Moisturizer + Broad-Spectrum SPF 50+ PA++++ [pH 5.8 · Mandatory final step]
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Esthetician & Cosmetic Chemist FAQ
What is the formulation pH and full INCI profile of The Ordinary Multi-Peptide + Copper Peptides 1% Serum (Buffet + Copper)?
The Ordinary Multi-Peptide + Copper Peptides 1% Serum (Buffet + Copper) is formulated at pH 6.2 ($32). Full INCI: Aqua (Water), Glycerin, Lactococcus Ferment Lysate, Copper Tripeptide-1, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Sodium Hyaluronate, Allantoin.
Which skincare actives conflict with The Ordinary Multi-Peptide + Copper Peptides 1% Serum (Buffet + Copper)?
Strictly incompatible with L-Ascorbic Acid, Glycolic Acid, Lactic Acid, Salicylic Acid, and Kojic Acid due to histidine protonation and copper chelation.
Is The Ordinary Multi-Peptide + Copper Peptides 1% Serum (Buffet + Copper) comedogenic or fungal-acne (Malassezia) safe?
Run the pre-loaded INCI analyzer above to inspect positional comedogenicity (0–5) and C12–C24 Malassezia lipid ester triggers for every ingredient in Multi-Peptide + Copper Peptides 1% Serum (Buffet + Copper).